Physiochemical stress induces tissue injury as a result of the detection of abnormal molecular patterns by sensory molecules of the innate immune system. Here, we have described how the recently discovered C-type lectin collectin-11 (CL-11, also known as CL-K1 and encoded by
Conrad A. Farrar, David Tran, Ke Li, Weiju Wu, Qi Peng, Wilhelm Schwaeble, Wuding Zhou, Steven H. Sacks
Acute-phase response of CL-11 and associated molecules in mouse kidney.
Detection of CL-11 and potential ligand (L-fucose) and complement activation product (C3d) are shown in normal mouse kidney and injured kidney after 50 minutes of ischemia and up to 24 hours of reperfusion. (