Mutations in the isocitrate dehydrogenase genes
Gary Kohanbash, Diego A. Carrera, Shruti Shrivastav, Brian J. Ahn, Naznin Jahan, Tali Mazor, Zinal S. Chheda, Kira M. Downey, Payal B. Watchmaker, Casey Beppler, Rolf Warta, Nduka A. Amankulor, Christel Herold-Mende, Joseph F. Costello, Hideho Okada
Syngeneic IDH-MUT murine gliomas demonstrate reduced chemokine- and IFN-γ pathway–related genes and CTL infiltration.
C57BL/6 mice received intracranial injections of 1 × 105 GL261 or SB28 glioma cells stably transfected with cDNA for either WT or the R132H form of IDH1. Day-21 tumors were removed from mice and further assessed. (