Hepatocyte death, which can be apoptosis or necrosis depending on the context, is a prominent feature of liver disease. The lectin concanavalin A (ConA) activates immune cells, resulting in inflammatory liver injury and hepatocyte necrosis. In this issue of the
Lily Dara, Zhang-Xu Liu, Neil Kaplowitz
ConA-induced liver necrosis.
ConA activates T cells and NKT cells, which secrete cytokines, such as IFN-γ and TNF, that are known to be critical for liver injury in this model. Günther et al. discovered that IFN-γ signaling induces MLKL above a critical threshold (