Taxol involution of collagen-induced arthritis: ultrastructural correlation with the inhibition of synovitis and neovascularization
AL Arsenault, Š Lhoták, WL Hunter… - Clinical immunology and …, 1998 - Elsevier
Collagen-induced arthritis (CIA) is an animal model of rheumatoid arthritis (RA) that can be
regressed with Taxol (paclitaxel), a chemotherapeutic agent. To identify structural changes
that occur with involution, the synovium from naive, untreated CIA, and Taxol-treated CIA
rats were evaluated by light microscopy plus transmission and scanning electron
microscopy. Analysis included detailed images of vascular networks using polymeric
corrosion casts. The CIA synovium was morphologically similar to human RA synovium. In …
regressed with Taxol (paclitaxel), a chemotherapeutic agent. To identify structural changes
that occur with involution, the synovium from naive, untreated CIA, and Taxol-treated CIA
rats were evaluated by light microscopy plus transmission and scanning electron
microscopy. Analysis included detailed images of vascular networks using polymeric
corrosion casts. The CIA synovium was morphologically similar to human RA synovium. In …