Cyclic AMP and Chloride-dependent Regulation of the Apical Constitutive Secretory Pathway in Colonic Epithelial Cells (∗)
T Jilling, KL Kirk - Journal of Biological Chemistry, 1996 - ASBMB
Epithelial cells of the colonic crypt engage in cAMP-mediated fluid and electrolyte secretion.
In addition to participating in electrolyte transport, colonic crypt cells also synthesize and
secrete a number of proteins and peptides that play a crucial role in mucosal homeostasis.
In the present study we show that cAMP regulates not only electrolyte secretion but also
polarized protein secretion in a tissue culture model of colonic crypt cells. We found that
apical but not basolateral protein secretion was stimulated by a physiological activator of the …
In addition to participating in electrolyte transport, colonic crypt cells also synthesize and
secrete a number of proteins and peptides that play a crucial role in mucosal homeostasis.
In the present study we show that cAMP regulates not only electrolyte secretion but also
polarized protein secretion in a tissue culture model of colonic crypt cells. We found that
apical but not basolateral protein secretion was stimulated by a physiological activator of the …
