[HTML][HTML] Phosphorylation and inhibition of rat glucocorticoid receptor transcriptional activation by glycogen synthase kinase-3 (GSK-3): species-specific differences …
I Rogatsky, CLM Waase, MJ Garabedian - Journal of Biological Chemistry, 1998 - ASBMB
Transcriptional activation by the glucocorticoid receptor (GR) is regulated by both
glucocorticoid binding and phosphorylation. The rat GR N-terminal transcriptional regulatory
domain contains four major phosphorylation sites: threonine 171 (Thr 171), serine 224 (Ser
224), serine 232 (Ser 232), and serine 246 (Ser 246). We have previously demonstrated that
Ser 224 and Ser 232 are phosphorylated by cyclin-dependent kinases, while Ser 246 is
phosphorylated by the c-Jun N-terminal kinase. We report here that the remaining GR …
glucocorticoid binding and phosphorylation. The rat GR N-terminal transcriptional regulatory
domain contains four major phosphorylation sites: threonine 171 (Thr 171), serine 224 (Ser
224), serine 232 (Ser 232), and serine 246 (Ser 246). We have previously demonstrated that
Ser 224 and Ser 232 are phosphorylated by cyclin-dependent kinases, while Ser 246 is
phosphorylated by the c-Jun N-terminal kinase. We report here that the remaining GR …