Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease: III. Failure of neuroantigen-specific immune …
SD Miller, SJ Gerety, MK Kennedy, JD Peterson… - Journal of …, 1990 - Elsevier
Intracerebral inoculation of Theiler's murine encephalomyelitis virus (TMEV) into susceptible
mouse strains produces a chronic demyelinating disease in which mononuclear cell-rich
infiltrates in the central nervous system (CNS) are prominent. Current evidence strongly
supports an immune-mediated basis for myelin breakdown, with an effector role proposed
for TMEV-specific, major histocompatibility complex (MHC) class II-restricted delayed-type
hypersensitivity (DTH) responses in which lymphokine-activated macrophages mediate …
mouse strains produces a chronic demyelinating disease in which mononuclear cell-rich
infiltrates in the central nervous system (CNS) are prominent. Current evidence strongly
supports an immune-mediated basis for myelin breakdown, with an effector role proposed
for TMEV-specific, major histocompatibility complex (MHC) class II-restricted delayed-type
hypersensitivity (DTH) responses in which lymphokine-activated macrophages mediate …
