Precocious cessation of intestinal macromolecular transport and digestive enzymes development by prostaglandin E2 in suckling rats

E Harada, Y Hashimoto, B Syuto - Comparative Biochemistry and …, 1994 - Elsevier
The effect of repeated oral administration of prostaglandin analogue (dmPGE 2) on intestinal
macromolecular transport and digestive enzymes development were investigated in the
suckling rats. By the administration of dmPGE 2 for 7 days, precocious induction of maltase
activity, depression of amylase activity and enhancement of trypsin activity in the pancreas
occurred. Absorption of bovine IgG was dose dependently depressed by drnPGE 2
treatments. The intestinal cessation was also observed in the adrenalectomized pups, but …