Anorectic activity of NG-nitro-L-arginine, an inhibitor of brain nitric oxide synthase, in obese Zucker rats
F Squadrito, G Calapai, D Cucinotta, D Altavilla… - European journal of …, 1993 - Elsevier
European journal of pharmacology, 1993•Elsevier
We investigated the effects of N G-nitro-L-arginine (L-NO Arg) administration (12.2, 25 mg/kg
ip) on food consumption and body weight of male obese Zucker rats (fa/fa) and in their lean
age-matched controls (FA/?; FA/FA), both groups aged 14 weeks. Acute or repeated
administration of L-NO Arg reduced food intake and body weight in both obese and lean
rats. However the lean rats showed tolerance to the L-NO Arg effects after 5 days of
treatment. L-NO Arg anorexia was suppressed by pretreatment with metergoline. These …
ip) on food consumption and body weight of male obese Zucker rats (fa/fa) and in their lean
age-matched controls (FA/?; FA/FA), both groups aged 14 weeks. Acute or repeated
administration of L-NO Arg reduced food intake and body weight in both obese and lean
rats. However the lean rats showed tolerance to the L-NO Arg effects after 5 days of
treatment. L-NO Arg anorexia was suppressed by pretreatment with metergoline. These …
Abstract
We investigated the effects of NG-nitro-L-arginine (L-NO Arg) administration (12.2, 25 mg/kg i.p.) on food consumption and body weight of male obese Zucker rats (fa/fa) and in their lean age-matched controls (FA/?;FA/FA), both groups aged 14 weeks. Acute or repeated administration of L-NO Arg reduced food intake and body weight in both obese and lean rats. However the lean rats showed tolerance to the L-NO Arg effects after 5 days of treatment. L-NO Arg anorexia was suppressed by pretreatment with metergoline. These results suggest that L-NO Arg may represent a new anorectic drug.
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