Glycoprotein (GP) Ib-IX-transfected cells roll on a von Willebrand factor matrix under flow: importance of the GPIb/actin-binding protein (ABP-280) interaction in …
SL Cranmer, P Ulsemer, BM Cooke, HH Salem… - Journal of biological …, 1999 - ASBMB
Adhesion of platelets to sites of vascular injury is critical for hemostasis and thrombosis and
is dependent on the binding of the vascular adhesive protein von Willebrand factor (vWf) to
the glycoprotein (GP) Ib-V-IX complex on the platelet surface. A unique but poorly defined
characteristic of this receptor/ligand interaction is its ability to support platelet adhesion
under conditions of high shear stress. To examine the structural domains of the GPIb-V-IX
complex involved in mediating cell adhesion under flow, we have expressed partial (GPIb …
is dependent on the binding of the vascular adhesive protein von Willebrand factor (vWf) to
the glycoprotein (GP) Ib-V-IX complex on the platelet surface. A unique but poorly defined
characteristic of this receptor/ligand interaction is its ability to support platelet adhesion
under conditions of high shear stress. To examine the structural domains of the GPIb-V-IX
complex involved in mediating cell adhesion under flow, we have expressed partial (GPIb …
