[HTML][HTML] Cooperative signaling by tumor necrosis factor receptors CD120a (p55) and CD120b (p75) in the expression of nitric oxide and inducible nitric oxide synthase …
DWH Riches, ED Chan, EA Zahradka… - Journal of Biological …, 1998 - ASBMB
Tumor necrosis factor-α (TNFα) is recognized by the cell-surface receptors CD120a (p55)
and CD120b (p75). In the present study, we have investigated the role of these receptors in
the expression of NO 2−, a stable metabolite of nitric oxide, and inducible nitric oxide
synthase (iNOS) by mouse macrophages. Specific antibody-mediated aggregation of
CD120a (p55) induced NO 2− accumulation in culture supernatants and iNOS mRNA
expression in macrophage lysates, whereas cross-linking of CD120b (p75) had a minimal …
and CD120b (p75). In the present study, we have investigated the role of these receptors in
the expression of NO 2−, a stable metabolite of nitric oxide, and inducible nitric oxide
synthase (iNOS) by mouse macrophages. Specific antibody-mediated aggregation of
CD120a (p55) induced NO 2− accumulation in culture supernatants and iNOS mRNA
expression in macrophage lysates, whereas cross-linking of CD120b (p75) had a minimal …
