Inhibition of Macrophage Ca2+-independent Phospholipase A2 by Bromoenol Lactone and Trifluoromethyl Ketones (∗)
EJ Ackermann, K Conde-Frieboes… - Journal of Biological …, 1995 - ASBMB
A novel Ca 2+-independent phospholipase A 2 (PLA 2) has recently been purified from the
murine macrophage-like cell line P388D 1 (Ackermann, EJ, Kempner, ES, and Dennis, EA
(1994) J. Biol. Chem. 269, 9227-9233). This enzyme is now shown to be inhibited by
palmitoyl trifluoromethyl ketone (PACOCF 3), arachidonyl trifluoromethyl ketone (AACOCF
3), and a bromoenol lactone (BEL). Both PACOCF 3 and AACOCF 3 were found to inhibit
the macrophage PLA 2 in a concentration-dependent manner. PACOCF 3 was found to be …
murine macrophage-like cell line P388D 1 (Ackermann, EJ, Kempner, ES, and Dennis, EA
(1994) J. Biol. Chem. 269, 9227-9233). This enzyme is now shown to be inhibited by
palmitoyl trifluoromethyl ketone (PACOCF 3), arachidonyl trifluoromethyl ketone (AACOCF
3), and a bromoenol lactone (BEL). Both PACOCF 3 and AACOCF 3 were found to inhibit
the macrophage PLA 2 in a concentration-dependent manner. PACOCF 3 was found to be …
