Association of an HLA-DQ allele with clinical tuberculosis
AE Goldfeld, JC Delgado, S Thim, MV Bozon… - Jama, 1998 - jamanetwork.com
Context.—Although tuberculosis (TB) is the leading worldwide cause of death due to an
infectious disease, the extent to which progressive clinical disease is associated with
genetic host factors remains undefined. Objective.—To determine the distribution of HLA
antigens and the frequency of 2 alleles of the tumor necrosis factor α (TNF-α) gene in
unrelated individuals with clinical TB (cases) compared with individuals with no history of
clinical TB (controls) in a population with a high prevalence of TB exposure. Design.—A 2 …
infectious disease, the extent to which progressive clinical disease is associated with
genetic host factors remains undefined. Objective.—To determine the distribution of HLA
antigens and the frequency of 2 alleles of the tumor necrosis factor α (TNF-α) gene in
unrelated individuals with clinical TB (cases) compared with individuals with no history of
clinical TB (controls) in a population with a high prevalence of TB exposure. Design.—A 2 …
