[HTML][HTML] Signal-transducing mechanisms involved in activation of the platelet collagen receptor integrin α2β1
SM Jung, M Moroi - Journal of Biological Chemistry, 2000 - ASBMB
Evidence was obtained about the mechanism responsible for platelet integrin α 2 β
activation by determining effects of various inhibitors on soluble collagen binding, a
parameter to assess integrin α 2 β 1 activation, in stimulated platelets. Agonists that can also
activate platelet glycoprotein IIb/IIIa are able to activate integrin α 2 β 1, but those operating
via glycoprotein Ib cannot. Activation of α 2 β 1 induced by low thrombin or collagen-related
peptide concentrations was almost completely inhibited by apyrase, and the inhibitors …
activation by determining effects of various inhibitors on soluble collagen binding, a
parameter to assess integrin α 2 β 1 activation, in stimulated platelets. Agonists that can also
activate platelet glycoprotein IIb/IIIa are able to activate integrin α 2 β 1, but those operating
via glycoprotein Ib cannot. Activation of α 2 β 1 induced by low thrombin or collagen-related
peptide concentrations was almost completely inhibited by apyrase, and the inhibitors …