Leukocytes play a central role in the pathogenesis of anti-glomerular basement membrane
glomerulonephritis (anti-GBM GN). Understanding the mechanisms underlying their
recruitment in the glomerulus is of critical importance, because this may lead to more
specific anti-inflammatory drug design. The requirement for integrins, especially from the β 2
group, and their Ig superfamily counter-receptors has been established, however, the role of
selectins remains controversial. An intravital microscopy technique was developed to study …