Isolation and characterization of full and truncated forms of human breast carcinoma protein BA46 from human milk fat globule membranes
MG Giuffrida, M Cavaletto, C Giunta, A Conti… - Journal of protein …, 1998 - Springer
MG Giuffrida, M Cavaletto, C Giunta, A Conti, J Godovac-Zimmermann
Journal of protein chemistry, 1998•SpringerWe have isolated and characterized two proteins of 50 and 30 kDa from human milk fat
globule membranes of healthy donors. N-terminal and internal sequencing revealed that the
50-kDa protein is the full-length human breast carcinoma protein BA46 that is highly
expressed in human breast tumors. The 30-kDa protein is a truncated form of protein BA46
which consists of the C-terminal factor V/VIII-like domain of BA46 and which appears to
anchor BA46 to the milk fat globule membrane. Defective release of the epidermal growth …
globule membranes of healthy donors. N-terminal and internal sequencing revealed that the
50-kDa protein is the full-length human breast carcinoma protein BA46 that is highly
expressed in human breast tumors. The 30-kDa protein is a truncated form of protein BA46
which consists of the C-terminal factor V/VIII-like domain of BA46 and which appears to
anchor BA46 to the milk fat globule membrane. Defective release of the epidermal growth …
Abstract
We have isolated and characterized two proteins of 50 and 30 kDa from human milk fat globule membranes of healthy donors. N-terminal and internal sequencing revealed that the 50-kDa protein is the full-length human breast carcinoma protein BA46 that is highly expressed in human breast tumors. The 30-kDa protein is a truncated form of protein BA46 which consists of the C-terminal factor V/VIII-like domain of BA46 and which appears to anchor BA46 to the milk fat globule membrane. Defective release of the epidermal growth factor domain containing a surface RGD motif may be related to involvement of BA46 in breast cancer
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