Irradiation induces increase of adhesion molecules and accumulation of β2-integrin-expressing cells in humans
J Handschel, FJ Prott, C Sunderkötter, D Metze… - International Journal of …, 1999 - Elsevier
Purpose: The purpose of our investigation was to describe the dose-and time-dependent
histomorphologic alterations of the irradiated tissue, the composition of the infiltrate, and the
expression patterns of various adhesion molecules. Methods and Materials: We analyzed
immunohistochemically alterations in oral mucosa in 13 head and neck cancer patients
before radiotherapy and with 30 Gy and 60 Gy. All had oral mucosa irradiation, with a final
dose of 60 Gy using conventional fractionation. Snap-frozen specimens were stained using …
histomorphologic alterations of the irradiated tissue, the composition of the infiltrate, and the
expression patterns of various adhesion molecules. Methods and Materials: We analyzed
immunohistochemically alterations in oral mucosa in 13 head and neck cancer patients
before radiotherapy and with 30 Gy and 60 Gy. All had oral mucosa irradiation, with a final
dose of 60 Gy using conventional fractionation. Snap-frozen specimens were stained using …