Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen
ML Smith, IT Chen, Q Zhan, I Bae, CY Chen, TM Gilmer… - Science, 1994 - science.org
ML Smith, IT Chen, Q Zhan, I Bae, CY Chen, TM Gilmer, MB Kastan, PM O'Connor…
Science, 1994•science.orgGADD45 is a ubiquitously expressed mammalian gene that is induced by DNA damage and
certain other stresses. Like another p53-regulated gene, p21WAF1/CIP1, whose product
binds to cyclin-dependent kinases (Cdk's) and proliferating cell nuclear antigen (PCNA),
GADD45 has been associated with growth suppression. Gadd45 was found to bind to
PCNA, a normal component of Cdk complexes and a protein involved in DNA replication
and repair. Gadd45 stimulated DNA excision repair in vitro and inhibited entry of cells into S …
certain other stresses. Like another p53-regulated gene, p21WAF1/CIP1, whose product
binds to cyclin-dependent kinases (Cdk's) and proliferating cell nuclear antigen (PCNA),
GADD45 has been associated with growth suppression. Gadd45 was found to bind to
PCNA, a normal component of Cdk complexes and a protein involved in DNA replication
and repair. Gadd45 stimulated DNA excision repair in vitro and inhibited entry of cells into S …
GADD45 is a ubiquitously expressed mammalian gene that is induced by DNA damage and certain other stresses. Like another p53-regulated gene, p21WAF1/CIP1, whose product binds to cyclin-dependent kinases (Cdk's) and proliferating cell nuclear antigen (PCNA), GADD45 has been associated with growth suppression. Gadd45 was found to bind to PCNA, a normal component of Cdk complexes and a protein involved in DNA replication and repair. Gadd45 stimulated DNA excision repair in vitro and inhibited entry of cells into S phase. These results establish GADD45 as a link between the p53-dependent cell cycle checkpoint and DNA repair.
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