Changes in epidermal growth factor receptor expression and competence to generate glia regulate timing and choice of differentiation in the retina
L Lillien, D Wancio - Molecular and Cellular Neuroscience, 1998 - Elsevier
Previous studies demonstrated that the level of epidermal growth factor receptors (EGF-Rs)
expressed by progenitor cells in the newborn (P0) rat retina was limiting for the generation of
Muller glial cells but not for proliferation. To determine whether EGF-R signaling biases cells
to generate a specific cell type or regulates more general processes during progenitor cell
development, we have introduced extra copies of the EGF-R into progenitor cells at earlier
stages (E15 and E18), when different cell types are produced. We show that progenitor cells …
expressed by progenitor cells in the newborn (P0) rat retina was limiting for the generation of
Muller glial cells but not for proliferation. To determine whether EGF-R signaling biases cells
to generate a specific cell type or regulates more general processes during progenitor cell
development, we have introduced extra copies of the EGF-R into progenitor cells at earlier
stages (E15 and E18), when different cell types are produced. We show that progenitor cells …