Recent advances in molecular recognition and signal transduction of active peptides: receptors for opioid peptides
BL Kieffer - Cellular and molecular neurobiology, 1995 - Springer
Cellular and molecular neurobiology, 1995•Springer
Opioid peptides are a family of structurally related neuromodulators which play a major role
in the control of nociceptive pathways. These peptides act through membrane receptors of
the nervous system, defined as μ, δ and κ and endowed with overlaping but distinct
pharmacological, anatomical and functional properties. 2. Recent cloning of an opioid
receptor gene family has opened the way to the use of recombinant DNA technology at the
receptor level. 3. This review focuses on the molecular cloning and functional …
in the control of nociceptive pathways. These peptides act through membrane receptors of
the nervous system, defined as μ, δ and κ and endowed with overlaping but distinct
pharmacological, anatomical and functional properties. 2. Recent cloning of an opioid
receptor gene family has opened the way to the use of recombinant DNA technology at the
receptor level. 3. This review focuses on the molecular cloning and functional …
Summary
1. Opioid peptides are a family of structurally related neuromodulators which play a major role in the control of nociceptive pathways. These peptides act through membrane receptors of the nervous system, defined asμ, δ andκ and endowed with overlaping but distinct pharmacological, anatomical and functional properties.
2. Recent cloning of an opioid receptor gene family has opened the way to the use of recombinant DNA technology at the receptor level.
3. This review focuses on the molecular cloning and functional characterization of opioid receptors and provides first insights into molecular aspects of opioid peptide recognition and signal transduction mechanisms, using the cloned receptors as investigation tools.
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