VIP elevates platelet cyclic AMP (cAMP) levels and inhibits in vitro platelet activation induced by platelet-activating factor (PAF)
CP Cox, J Linden, SI Said - Peptides, 1984 - Elsevier
Abstract Platelet-activating factor (PAF), a potent endogenous phospholipid released by a
variety of mammalian cells, induces platelet activation in vivo and in vitro. Little is known,
however, about the physiological modulation of its actions. We have examined the ability of
two naturally occurring compounds which stimulate cAMP production, vasoactive intestinal
peptide (VIP) and prostacyclin (PGI 2), to inhibit PAF-induced platelet aggregation and
secretion in vitro. Washed,[3 H] serotonin-labeled, rabbit platelets were incubated 60 sec in …
variety of mammalian cells, induces platelet activation in vivo and in vitro. Little is known,
however, about the physiological modulation of its actions. We have examined the ability of
two naturally occurring compounds which stimulate cAMP production, vasoactive intestinal
peptide (VIP) and prostacyclin (PGI 2), to inhibit PAF-induced platelet aggregation and
secretion in vitro. Washed,[3 H] serotonin-labeled, rabbit platelets were incubated 60 sec in …
