[PDF][PDF] SPECT imaging of striatal dopamine release after amphetamine challenge

M Laruelle, A Abi-Dargham, CH van Dyck… - Journal of Nuclear …, 1995 - Soc Nuclear Med
M Laruelle, A Abi-Dargham, CH van Dyck, W Rosenblatt, Y Zea-Ponce, SS Zoghbi…
Journal of Nuclear Medicine, 1995Soc Nuclear Med
In this study, we applied a tracer programmedinfusion technique (20, 21) with the SPECT D2
receptor probe [†œ-@ I] IBZM (22) to establish a stable baseline for evaluation of the d-
amphetamine induced dopamine release in hu mans. Iodine-123-IBZMis a dopamine D2
and D3 antago nist characterized by high selectivity and relatively mod erate affinity (KD at
37ÂCis 0.43 nM) for both D2 and D3
In this study, we applied a tracer programmedinfusion technique (20, 21) with the SPECT D2 receptor probe [†œ-@ I] IBZM (22) to establish a stable baseline for evaluation of the d-amphetamine induced dopamine release in hu mans. Iodine-123-IBZMis a dopamine D2 and D3 antago nist characterized by high selectivity and relatively mod erate affinity (KD at 37ÂCis 0.43 nM) for both D2 and D3
Society of Nuclear Medicine and Molecular Imaging