Amphetamine-induced dopamine release in human ventral striatum correlates with euphoria

WC Drevets, C Gautier, JC Price, DJ Kupfer… - Biological …, 2001 - Elsevier
Background: Studies in experimental animals have implicated the mesolimbic dopaminergic
projections into the ventral striatum in the neural processes underlying behavioral
reinforcement and motivated behavior; however, understanding the relationship between
subjective emotional experience and ventral striatal dopamine (DA) release has awaited
human studies. Using positron emission tomography (PET), we correlated the change in
endogenous dopamine concentrations following dextroamphetamine (AMPH) administration …