This issue of the ARCHIVES includes three new reports of functional brain imaging studies
in patients with obsessive-compulsive disorder (OCD). 1-3 These articles add to a growing
literature on changes in either regional brain metabolism or blood flow in patients with OCD.
Although the first such article was published only 5 years ago, 4 there is already a
consensus developing toward a neuroanatomic model of the pathophysiologic
characteristics of this mysterious syndrome. In this Comment, I examine the evidence for …