Neural activity related to drug craving in cocaine addiction

CD Kilts, JB Schweitzer, CK Quinn… - Archives of general …, 2001 - jamanetwork.com
Background Crack cocaine dependence and addiction is typically associated with frequent
and intense drug wanting or craving triggered by internal or environmental cues associated
with past drug use. Methods Water O 15 positron emission tomography (PET) studies were
used to localize alterations in synaptic activity related to cue-induced drug craving in 8 crack
cocaine–dependent African American men. In a novel approach, script-guided imagery of
autobiographical memories were used as individualized cues to internally generate a …