Cellular and molecular mechanisms of drug dependence

GF Koob, FE Bloom - Science, 1988 - science.org
GF Koob, FE Bloom
Science, 1988science.org
The molecular and cellular actions of three classes of abused drugs—opiates,
psychostimulants, and ethanol—are reviewed in the context of behavioral studies of drug
dependence. The immediate effects of drugs are compared to those observed after long-
term exposure. A neurobiological basis for drug dependence is proposed from the linkage
between the cellular and behavioral effects of these drugs.
The molecular and cellular actions of three classes of abused drugs—opiates, psychostimulants, and ethanol—are reviewed in the context of behavioral studies of drug dependence. The immediate effects of drugs are compared to those observed after long-term exposure. A neurobiological basis for drug dependence is proposed from the linkage between the cellular and behavioral effects of these drugs.
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