Decreased gray matter concentration in the insular, orbitofrontal, cingulate, and temporal cortices of cocaine patients

TR Franklin, PD Acton, JA Maldjian, JD Gray… - Biological …, 2002 - Elsevier
Background: Structural deficiencies within limbic and prefrontal regions may contribute to
the characteristic drug-seeking and drug-taking behaviors that prevail in persons dependent
on cocaine. To date, a focal structural analysis of the brains of cocaine patients has not been
undertaken. Methods: We used voxel based morphometry in conjunction with statistical
parametric mapping on the structural magnetic resonance images of cocaine-dependent (n=
13) and cocaine-naive individuals (n= 16) to assess differences between the two groups in …