[HTML][HTML] Identification of amino acid residues and protein kinases involved in the regulation of NFATc subcellular localization
CM Porter, MA Havens, NA Clipstone - Journal of Biological Chemistry, 2000 - ASBMB
The subcellular localization of the transcription factor NFATc is tightly regulated by the
calcium-regulated phosphatase calcineurin, which acts to directly dephosphorylate NFATc,
causing its rapid translocation from the cytoplasm to the nucleus. The calcineurin-mediated
nuclear localization of NFATc is opposed by poorly defined protein kinases that act either to
directly antagonize nuclear import or, alternatively, to promote nuclear export. Here, we
provide evidence that the cellular protein kinases JNK, ERK, p38, and CK2 (formerly casein …
calcium-regulated phosphatase calcineurin, which acts to directly dephosphorylate NFATc,
causing its rapid translocation from the cytoplasm to the nucleus. The calcineurin-mediated
nuclear localization of NFATc is opposed by poorly defined protein kinases that act either to
directly antagonize nuclear import or, alternatively, to promote nuclear export. Here, we
provide evidence that the cellular protein kinases JNK, ERK, p38, and CK2 (formerly casein …