Verapamil has been shown to attenuate the extent of myocardial injury in murine models of
chronic Trypanosoma cruzi infection. Infected mice treated with verapamil have significantly
lower myocardial expression of inducible nitric oxide synthase and cytokines and
substantially less inflammatory infiltrate and myocyte necrosis at necropsy. In the present
study, we examined the cardiac structural and functional correlates of verapamil treatment in
CD1 mice infected with the Brazil strain of T. cruzi using serial transthoracic …