[HTML][HTML] The serum protein α2-HS glycoprotein/fetuin inhibits apatite formation in vitro and in mineralizing calvaria cells: a possible role in mineralization and calcium …
T Schinke, C Amendt, A Trindl, O Pöschke… - Journal of Biological …, 1996 - ASBMB
We present data suggesting a function of α 2-HS glycoproteins/fetuins in serum and in
mineralization, namely interference with calcium salt precipitation. Fetuins occur in high
serum concentration during fetal life. They accumulate in bones and teeth as a major fraction
of noncollagenous bone proteins. The expression pattern in fetal mice confirms that fetuin is
predominantly made in the liver and is accumulated in the mineralized matrix of bones. We
arrived at a hypothesis on the molecular basis of fetuin function in bones using primary rat …
mineralization, namely interference with calcium salt precipitation. Fetuins occur in high
serum concentration during fetal life. They accumulate in bones and teeth as a major fraction
of noncollagenous bone proteins. The expression pattern in fetal mice confirms that fetuin is
predominantly made in the liver and is accumulated in the mineralized matrix of bones. We
arrived at a hypothesis on the molecular basis of fetuin function in bones using primary rat …
