Mechanisms of inhibition of calcification.
NC BLUMENTHAL - Clinical Orthopaedics and Related Research …, 1989 - journals.lww.com
Mineralization processes in the body are controlled by physicochemical and cellular
regulation of hydroxyapatite (HA) nucleators and inhibitors. The chemical mechanism of
action of HA inhibitors has been studied in vitro using solution pH-stat techniques or Types I
and II collagen gel diffusion systems. Three biologically relevant systems are used with
these methodologies:(1) transformation of amorphous calcium phosphate (ACP) to
crystalline HA;(2) direct formation of HA; and (3) growth of HA crystals. Several different …
regulation of hydroxyapatite (HA) nucleators and inhibitors. The chemical mechanism of
action of HA inhibitors has been studied in vitro using solution pH-stat techniques or Types I
and II collagen gel diffusion systems. Three biologically relevant systems are used with
these methodologies:(1) transformation of amorphous calcium phosphate (ACP) to
crystalline HA;(2) direct formation of HA; and (3) growth of HA crystals. Several different …