Intracellular reactive oxygen species mediate the linkage of Na+/K+-ATPase to hypertrophy and its marker genes in cardiac myocytes
Z Xie, P Kometiani, J Liu, J Li, JI Shapiro… - Journal of Biological …, 1999 - ASBMB
We showed before that in cardiac myocytes partial inhibition of Na+/K+-ATPase by nontoxic
concentrations of ouabain causes hypertrophy and transcriptional regulations of growth-
related marker genes through multiple Ca 2+-dependent signal pathways many of which
involve Ras and p42/44 mitogen-activated protein kinases. The aim of this work was to
explore the roles of intracellular reactive oxygen species (ROS) in these ouabain-initiated
pathways. Ouabain caused a rapid generation of ROS within the myocytes that was …
concentrations of ouabain causes hypertrophy and transcriptional regulations of growth-
related marker genes through multiple Ca 2+-dependent signal pathways many of which
involve Ras and p42/44 mitogen-activated protein kinases. The aim of this work was to
explore the roles of intracellular reactive oxygen species (ROS) in these ouabain-initiated
pathways. Ouabain caused a rapid generation of ROS within the myocytes that was …
