Thioredoxin overexpression in transgenic mice
H Nakamura, A Mitsui, J Yodoi - Methods in enzymology, 2002 - Elsevier
There is accumulating evidence that thioredoxin (TRX) plays a crucial role in intracellular
and extracellular various biological functions including signal transduction and
cytoprotection. 1 TRX is induced by various oxidative stresses including viral infection and
translocated from the cytoplasm into the nucleus on oxidative stress. In the nucleus, TRX
interacts with redox factor 1 (Ref-1), an endoexonuclease, to enhance the DNA-binding
activity of transcription factors such as AP-1 and p53. 2, 3 TRX shows cytoprotective …
and extracellular various biological functions including signal transduction and
cytoprotection. 1 TRX is induced by various oxidative stresses including viral infection and
translocated from the cytoplasm into the nucleus on oxidative stress. In the nucleus, TRX
interacts with redox factor 1 (Ref-1), an endoexonuclease, to enhance the DNA-binding
activity of transcription factors such as AP-1 and p53. 2, 3 TRX shows cytoprotective …
