Onset of multiple sclerosis associated with anti-TNF therapy

NL Sicotte, RR Voskuhl - Neurology, 2001 - AAN Enterprises
Neurology, 2001AAN Enterprises
Therapies aimed at inhibiting tumor necrosis factor (TNF), a proinflammatory cytokine
implicated in autoimmune disease are effective, especially for rheumatoid arthritis. We report
a patient with new onset MS closely associated with the initiation of anti-TNF therapy for
juvenile rheumatoid arthritis. It is possible that the inhibition of TNF triggered MS in this
individual.
Therapies aimed at inhibiting tumor necrosis factor (TNF), a proinflammatory cytokine implicated in autoimmune disease are effective, especially for rheumatoid arthritis. We report a patient with new onset MS closely associated with the initiation of anti-TNF therapy for juvenile rheumatoid arthritis. It is possible that the inhibition of TNF triggered MS in this individual.
American Academy of Neurology