A germline hMSH2 alteration is unrelated to colonic microsatellite instability in patients with ulcerative colitis
AE Noffsinger, JM Belli, F Fogt, J Fischer, H Goldman… - Human pathology, 1999 - Elsevier
Recently, a polymorphism in the hMSH2 DNA mismatch repair gene has been associated
with the development of dysplasia in ulcerative colitis (UC) patients. This polymorphism is of
interest because DNA mismatch repair defects result in alterations in microsatellite stability.
The current study was designed to determine whether this hMSH2 polymorphism associates
with the development of microsatellite instability and dysplasia in UC patients. The hMSH2
genotype of 96 UC patients was determined by direct DNA sequencing. In addition, we …
with the development of dysplasia in ulcerative colitis (UC) patients. This polymorphism is of
interest because DNA mismatch repair defects result in alterations in microsatellite stability.
The current study was designed to determine whether this hMSH2 polymorphism associates
with the development of microsatellite instability and dysplasia in UC patients. The hMSH2
genotype of 96 UC patients was determined by direct DNA sequencing. In addition, we …