The hepatic vagal nerve is receptive to incretin hormone glucagon-like peptide-l, but not to glucose-dependent insulinotropic polypeptide, in the portal vein
M Nishizawa, H Nakabayashi, K Uchida… - Journal of the autonomic …, 1996 - Elsevier
To examine whether incretin hormones, truncated glucagon-like peptide-1 (tGLP-1) and
glucose-dependent insulinotropic polypeptide (GIP), are recognized by the hepatic vagal
nerve, changes of the impulse discharge rate in the afferent vagus upon their intraportal
administrations were measured in situ in rats anesthetized with urethan and chloralose. One-
min injection of tGLP-1 at a periphysiological dose of 0.2 pmol or a pharmacological dose of
4.0 pmol, but not of the vehicle, significantly facilitated the hepatic vagal afferents. However …
glucose-dependent insulinotropic polypeptide (GIP), are recognized by the hepatic vagal
nerve, changes of the impulse discharge rate in the afferent vagus upon their intraportal
administrations were measured in situ in rats anesthetized with urethan and chloralose. One-
min injection of tGLP-1 at a periphysiological dose of 0.2 pmol or a pharmacological dose of
4.0 pmol, but not of the vehicle, significantly facilitated the hepatic vagal afferents. However …