Pharmacological neuroprotection against the consequences of seizures can be considered
as primary neuroprotection where the object is to diminish the initial insult by suppressing
the seizure activity or diminishing the associated ionic fluxes (of which the entry of Na+ and
Ca 2+ are the most significant), and secondary neuroprotection where the target is some
later event in the chain linking ionic changes to altered brain morphology or function. Thus
primary neuroprotection is provided by antiepileptic drugs and compounds acting on voltage …