[HTML][HTML] Mitochondrial permeability transition and oxidative stress
FEBS letters, 2001•Elsevier
Mitochondrial permeability transition (MPT) is a non-selective inner membrane
permeabilization that may precede necrotic and apoptotic cell death. Although this process
has a specific inhibitor, cyclosporin A, little is known about the nature of the proteinaceous
pore that results in MPT. Here, we review data indicating that MPT is not a consequence of
the opening of a pre-formed pore, but the consequence of oxidative damage to pre-existing
membrane proteins.
permeabilization that may precede necrotic and apoptotic cell death. Although this process
has a specific inhibitor, cyclosporin A, little is known about the nature of the proteinaceous
pore that results in MPT. Here, we review data indicating that MPT is not a consequence of
the opening of a pre-formed pore, but the consequence of oxidative damage to pre-existing
membrane proteins.
Mitochondrial permeability transition (MPT) is a non-selective inner membrane permeabilization that may precede necrotic and apoptotic cell death. Although this process has a specific inhibitor, cyclosporin A, little is known about the nature of the proteinaceous pore that results in MPT. Here, we review data indicating that MPT is not a consequence of the opening of a pre-formed pore, but the consequence of oxidative damage to pre-existing membrane proteins.
Elsevier