[HTML][HTML] Calpain and mitochondria in ischemia/reperfusion injury
M Chen, DJ Won, S Krajewski, RA Gottlieb - Journal of Biological Chemistry, 2002 - ASBMB
Studies of ischemia/reperfusion (I/R) injury and preconditioning have shown that ion
homeostasis, particularly calcium homeostasis, is critical to limiting tissue damage.
However, the relationship between ion homeostasis and specific cell death pathways has
not been investigated in the context of I/R. Previously we reported that calpain cleaved Bid in
the absence of detectable caspase activation (1). In this study, we have shown that an
inhibitor of the sodium/hydrogen exchanger prevented calpain activation after I/R. Calpain …
homeostasis, particularly calcium homeostasis, is critical to limiting tissue damage.
However, the relationship between ion homeostasis and specific cell death pathways has
not been investigated in the context of I/R. Previously we reported that calpain cleaved Bid in
the absence of detectable caspase activation (1). In this study, we have shown that an
inhibitor of the sodium/hydrogen exchanger prevented calpain activation after I/R. Calpain …