Reduction in the stearic to oleic acid ratio in human malignant liver neoplasms.

CB Wood, NA Habib, K Apostolov… - European Journal of …, 1985 - europepmc.org
CB Wood, NA Habib, K Apostolov, A Thompson, W Barker, M Hershman, LH Blumgart
European Journal of Surgical Oncology: the Journal of the European …, 1985europepmc.org
Total lipid extracts of liver tissue from 14 patients with primary and secondary liver tumours
were analysed for relative values of saturation of 18 carbon chain length fatty acids (C18FA).
The saturation indices (ratio C18S: C18u) of the tumour areas were significantly and
consistently lower than the corresponding values in the non-tumour areas (P less than
0.001). It is proposed that the relative increase in unsaturated C18FA (oleic acid) could
prove to be a chemical marker reflecting deficient cellular control of the desaturation of …
Total lipid extracts of liver tissue from 14 patients with primary and secondary liver tumours were analysed for relative values of saturation of 18 carbon chain length fatty acids (C18FA). The saturation indices (ratio C18S: C18u) of the tumour areas were significantly and consistently lower than the corresponding values in the non-tumour areas (P less than 0.001). It is proposed that the relative increase in unsaturated C18FA (oleic acid) could prove to be a chemical marker reflecting deficient cellular control of the desaturation of stearic acid.
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