[HTML][HTML] Sphingosine 1-phosphate-induced endothelial cell migration requires the expression of EDG-1 and EDG-3 receptors and Rho-dependent activation of αvβ3 …
Sphingosine 1-phosphate (SPP), a platelet-derived bioactive lysophospholipid, is a
regulator of angiogenesis. However, molecular mechanisms involved in SPP-induced
angiogenic responses are not fully defined. Here we report the molecular mechanisms
involved in SPP-induced human umbilical vein endothelial cell (HUVEC) adhesion and
migration. SPP-induced HUVEC migration is potently inhibited by antisense phosphothioate
oligonucleotides against EDG-1 as well as EDG-3 receptors. In addition, C3 exotoxin …
regulator of angiogenesis. However, molecular mechanisms involved in SPP-induced
angiogenic responses are not fully defined. Here we report the molecular mechanisms
involved in SPP-induced human umbilical vein endothelial cell (HUVEC) adhesion and
migration. SPP-induced HUVEC migration is potently inhibited by antisense phosphothioate
oligonucleotides against EDG-1 as well as EDG-3 receptors. In addition, C3 exotoxin …