Quality control in the endoplasmic reticulum protein factory
R Sitia, I Braakman - Nature, 2003 - nature.com
R Sitia, I Braakman
Nature, 2003•nature.comThe endoplasmic reticulum (ER) is a factory where secretory proteins are manufactured, and
where stringent quality-control systems ensure that only correctly folded proteins are sent to
their final destinations. The changing needs of the ER factory are monitored by integrated
signalling pathways that constantly adjust the levels of folding assistants. ER chaperones
and signalling molecules are emerging as drug targets in amyloidoses and other protein-
conformational diseases.
where stringent quality-control systems ensure that only correctly folded proteins are sent to
their final destinations. The changing needs of the ER factory are monitored by integrated
signalling pathways that constantly adjust the levels of folding assistants. ER chaperones
and signalling molecules are emerging as drug targets in amyloidoses and other protein-
conformational diseases.
Abstract
The endoplasmic reticulum (ER) is a factory where secretory proteins are manufactured, and where stringent quality-control systems ensure that only correctly folded proteins are sent to their final destinations. The changing needs of the ER factory are monitored by integrated signalling pathways that constantly adjust the levels of folding assistants. ER chaperones and signalling molecules are emerging as drug targets in amyloidoses and other protein-conformational diseases.
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