Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol.
JM Oliver, DL Burg, BS Wilson, JL McLaughlin… - Journal of Biological …, 1994 - ASBMB
In RBL-2H3 rat tumor mast cells, antigens that cross-link the high affinity cell surface IgE
receptor, Fc epsilon R1, activate at least two receptor-associated protein-tyrosine kinases,
Lyn and Syk, and cause the tyrosine phosphorylation of the receptor beta and gamma
subunits, PLC gamma 1, Vav, and other proteins. Cross-linking antigens also induce
increased phosphatidylinositol turnover, Ca2+ mobilization, secretion, actin polymerization,
spreading, and membrane ruffling. We have used the protein-tyrosine kinase inhibitor …
receptor, Fc epsilon R1, activate at least two receptor-associated protein-tyrosine kinases,
Lyn and Syk, and cause the tyrosine phosphorylation of the receptor beta and gamma
subunits, PLC gamma 1, Vav, and other proteins. Cross-linking antigens also induce
increased phosphatidylinositol turnover, Ca2+ mobilization, secretion, actin polymerization,
spreading, and membrane ruffling. We have used the protein-tyrosine kinase inhibitor …