[HTML][HTML] Preservation of base-line hemodynamic function and loss of inducible cardioprotection in adult mice lacking protein kinase Cϵ
MO Gray, HZ Zhou, I Schafhalter-Zoppoth, P Zhu… - Journal of Biological …, 2004 - ASBMB
Signaling pathways involving protein kinase C isozymes are modulators of cardiovascular
development and response to injury. Protein kinase Cϵ activation in cardiac myocytes
reduces necrosis caused by coronary artery disease. However, it is unclear whether protein
kinase Cϵ function is required for normal cardiac development or inducible protection
against oxidative stress. Protein kinase Cδ activation is also observed during cardiac
preconditioning. However, its role as a promoter or inhibitor of injury is controversial. We …
development and response to injury. Protein kinase Cϵ activation in cardiac myocytes
reduces necrosis caused by coronary artery disease. However, it is unclear whether protein
kinase Cϵ function is required for normal cardiac development or inducible protection
against oxidative stress. Protein kinase Cδ activation is also observed during cardiac
preconditioning. However, its role as a promoter or inhibitor of injury is controversial. We …