Spinal administration of prostaglandin E2 or prostaglandin F2α primarily produces mechanical hyperalgesia that is mediated by nociceptive specific spinal dorsal horn …
ME Turnbach, DS Spraggins, A Randich - Pain, 2002 - Elsevier
The effects of intrathecal (it) administration of prostaglandin E2 (PGE2) and prostaglandin
F2α (PGF2α) on behavioral and spinal neuronal responses to mechanical and thermal
stimuli were examined in rats. it Administration of either PGE2 (1–100nmol) or PGF2α (1–
100nmol) produced a robust, dose-dependent mechanical hyperalgesia, but only a weak
thermal hyperalgesia and touch-evoked allodynia. Spinal administration of either PGE2
(100pmol–100nmol) or PGF2α (1–100nmol) produced dose-dependent increases in …
F2α (PGF2α) on behavioral and spinal neuronal responses to mechanical and thermal
stimuli were examined in rats. it Administration of either PGE2 (1–100nmol) or PGF2α (1–
100nmol) produced a robust, dose-dependent mechanical hyperalgesia, but only a weak
thermal hyperalgesia and touch-evoked allodynia. Spinal administration of either PGE2
(100pmol–100nmol) or PGF2α (1–100nmol) produced dose-dependent increases in …