[HTML][HTML] Induction of Gαq-specific antisense RNA in vivo causes increased body mass and hyperadiposity
PA Galvin-Parton, X Chen, CM Moxham… - Journal of Biological …, 1997 - ASBMB
Transgenic BDF-1 mice harboring an inducible, tissue-specific transgene for RNA antisense
to Gα q provide a model in which to study a loss-of-function mutant of Gα q in vivo Gα q
deficiency induced in liver and white adipose tissue at birth produced increased body mass
and hyperadiposity within 5 weeks of birth that persisted throughout adult life. Gα q-deficient
adipocytes display reduced lipolytic responses, shown to reflect a newly discovered, α 1-
adrenergic regulation of lipolysis. This α 1-adrenergic response via phosphoinositide …
to Gα q provide a model in which to study a loss-of-function mutant of Gα q in vivo Gα q
deficiency induced in liver and white adipose tissue at birth produced increased body mass
and hyperadiposity within 5 weeks of birth that persisted throughout adult life. Gα q-deficient
adipocytes display reduced lipolytic responses, shown to reflect a newly discovered, α 1-
adrenergic regulation of lipolysis. This α 1-adrenergic response via phosphoinositide …
