Antitransforming growth factor–β antibody 1D11 ameliorates normal tissue damage caused by high-dose radiation

MS Anscher, B Thrasher, Z Rabbani, B Teicher… - International Journal of …, 2006 - Elsevier
Purpose The aim of this study was to determine whether a neutralizing transforming growth
factor–β (TGFβ) antibody can prevent radiation (RT) induced lung injury. Methods and
Materials Fractionated and sham right lung irradiation in Fischer 344 rats was delivered to
assess the radioprotective effect of the antibodies. Animals were divided into the following
groups:(1) control (sham RT, control antibody 13C4);(2) RT (800cGy x 5)+ 13C4);(3) RT+ 0.1
mg/kg 1D11 anti-TGFβ antibody; and (4) RT+ 1 mg/kg 1D11 antibody. Antibodies were …