Selective uptake of HDL cholesteryl esters and cholesterol efflux from mouse peritoneal macrophages independent of SR-BI
M Brundert, J Heeren, M Bahar-Bayansar, A Ewert… - Journal of lipid …, 2006 - ASBMB
Scavenger receptor class B type I (SR-BI) mediates the selective uptake of HDL cholesteryl
esters (CEs) and facilitates the efflux of unesterified cholesterol. SR-BI expression in
macrophages presumably plays a role in atherosclerosis. The role of SR-BI for selective CE
uptake and cholesterol efflux in macrophages was explored. Macrophages and HDL
originated from wild-type (WT) or SR-BI knockout (KO; homozygous) mice. For uptake,
macrophages were incubated in medium containing 125 I-/3 H-labeled HDL. For lipid …
esters (CEs) and facilitates the efflux of unesterified cholesterol. SR-BI expression in
macrophages presumably plays a role in atherosclerosis. The role of SR-BI for selective CE
uptake and cholesterol efflux in macrophages was explored. Macrophages and HDL
originated from wild-type (WT) or SR-BI knockout (KO; homozygous) mice. For uptake,
macrophages were incubated in medium containing 125 I-/3 H-labeled HDL. For lipid …
