Essential role of dendritic cell CD80/CD86 costimulation in the induction, but not reactivation, of TH2 effector responses in a mouse model of asthma
LS van Rijt, N Vos, M Willart, A KleinJan… - Journal of Allergy and …, 2004 - Elsevier
BACKGROUND: Airway dendritic cells (DCs) are crucial for the generation of TH2 cells from
naive T cells during sensitization and for reactivation of primed TH2 cells on allergen
challenge in mouse models of asthma. It is unknown whether CD80/CD86 costimulation is
necessary during both phases of the response because primed T cells rely less on
costimulatory molecules compared with naive T cells. OBJECTIVE: We sought to study the
contribution of CD80/CD86 costimulatory molecules on DCs during sensitization or …
naive T cells during sensitization and for reactivation of primed TH2 cells on allergen
challenge in mouse models of asthma. It is unknown whether CD80/CD86 costimulation is
necessary during both phases of the response because primed T cells rely less on
costimulatory molecules compared with naive T cells. OBJECTIVE: We sought to study the
contribution of CD80/CD86 costimulatory molecules on DCs during sensitization or …