Genetically-modified-animal models for human infections: the Listeria paradigm
M Lecuit, P Cossart - Trends in molecular medicine, 2002 - cell.com
M Lecuit, P Cossart
Trends in molecular medicine, 2002•cell.comSeveral human pathogens exhibit a restricted host-tropism, relying on the species-specific
interaction of microbial ligand (s) with host receptor (s). This specificity accounts for some of
the difficulties in modeling human infections in animals. The discovery of L. monocytogenes
host-specificity and elucidation of the underlying mechanism has led to the generation of
transgenic mice expressing one of its human receptors, E-cadherin. This model is presented
here as a paradigm of a genetically-modified-animal model for studying a human infectious …
interaction of microbial ligand (s) with host receptor (s). This specificity accounts for some of
the difficulties in modeling human infections in animals. The discovery of L. monocytogenes
host-specificity and elucidation of the underlying mechanism has led to the generation of
transgenic mice expressing one of its human receptors, E-cadherin. This model is presented
here as a paradigm of a genetically-modified-animal model for studying a human infectious …
Abstract
Several human pathogens exhibit a restricted host-tropism, relying on the species-specific interaction of microbial ligand(s) with host receptor(s). This specificity accounts for some of the difficulties in modeling human infections in animals. The discovery of L. monocytogenes host-specificity and elucidation of the underlying mechanism has led to the generation of transgenic mice expressing one of its human receptors, E-cadherin. This model is presented here as a paradigm of a genetically-modified-animal model for studying a human infectious disease.
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